2026PMID 41576937
Charting the translational pathway: ISSCR best practices for the development of PSC-derived therapies
Barry J, Abranches E, Baptista RP, Barry C, Brandsten C, Bruce K, et al.
Publications
58 peer-reviewed publications.
Research output spanning iPSC biology, cell and gene therapy, bioengineered tissues, and autonomous biomanufacturing.
58 publications
2025PMID 40961946
Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular degeneration: Low-dose clinical outcomes
Rao RC, Arduini BL, Borden S, Sareen D, Svendsen C, Lee P, et al.
2025PMID 40783300
Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data"
Vidović D, Shamsaei B, Schürer SC, Kogan P, Chojnacki S, Kouril M, et al.
2025PMID 40346963
Filamented Light (FLight) Biofabrication of Aligned Fibrillar Structures to Direct 3D Cell Organization Within Microgels
Joshi A, Kamaraj M, Moghimi N, Heidari H, Aghamaleky-Sarvestany A, Rahim CSA, et al.
2025PMID 40089066
Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data
Vidović D, Shamsaei B, Schürer SC, Kogan P, Chojnacki S, Kouril M, et al.
2025PMID 40441139
Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
Workman MJ, Lim RG, Wu J, Frank A, Ornelas L, Panther L, et al.
2024PMID 39796045
Identification of Disease-Relevant, Sex-Based Proteomic Differences in iPSC-Derived Vascular Smooth Muscle Cells
Ariyasinghe NR, Gupta D, Escopete S, Rai D, Stotland A, Sundararaman N, et al.
2024PMID 39211096
Identification of Disease-relevant, Sex-based Proteomic Differences in iPSC-derived Vascular Smooth Muscle
Ariyasinghe NR, Gupta D, Escopete S, Stotland AB, Sundararaman N, Ngu B, et al.
2024PMID 38697975
Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls
Tsitkov S, Valentine K, Kozareva V, Donde A, Frank A, Lei S, et al.
2023PMID 37306406
Proteomics of novel induced pluripotent stem cell-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line
Ariyasinghe NR, de Souza Santos R, Gross A, Aghamaleky-Sarvestany A, Kreimer S, Escopete S, et al.
2023PMID 37209468
Generation of isogenic and homozygous MEN1 mutant cell lines from patient-derived iPSCs using CRISPR/Cas9
Even-Zohar N, Metin-Armagan D, Ben-Shlomo A, Sareen D, Melmed S
2023PMID 36764301
Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
Workman MJ, Lim RG, Wu J, Frank A, Ornelas L, Panther L, et al.
2023PMID 36631473
NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency
Matlock AD, Vaibhav V, Holewinski R, Venkatraman V, Dardov V, Manalo DM, et al.
2022PMID 35115730
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
Baxi EG, Thompson T, Li J, Kaye JA, Lim RG, Wu J, et al.
2021PMID 34746695
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
NeuroLINCS Consortium, Li J, Lim RG, Kaye JA, Dardov V, Coyne AN, et al.
2021PMID 34282405
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells
Shaharuddin SH, Wang V, Santos RS, Gross A, Wang Y, Jawanda H, et al.
2021PMID 34238469
Hypothalamus and neuroendocrine diseases: The use of human-induced pluripotent stem cells for disease modeling
de Souza Santos R, Gross AR, Sareen D
2020PMID 32673563
GCRepeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, et al.
2020PMID 32450543
Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936
Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, et al.
2020PMID 32521508
Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao W, Beers DR, Thonhoff JR, Thome AD, Faridar A, Wang J, et al.
2020PMID 32560741
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, et al.
2019PMID 30712056
Retraction Note: Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives
Rajamani U, Gross AR, Ocampo C, Andres AM, Gottlieb RA, Sareen D
2018PMID 29681516
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
Rajamani U, Gross AR, Hjelm BE, Sequeira A, Vawter MP, Tang J, et al.
2018PMID 29576540
Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development
Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, et al.
2017PMID 29199020
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, et al.
2017PMID 29116112
A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries
Xiong Y, Soumillon M, Wu J, Hansen J, Hu B, van Hasselt JGC, et al.
2017PMID 28878359
Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium
Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, et al.
2017PMID 28794470
Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives
Rajamani U, Gross AR, Ocampo C, Andres AM, Gottlieb RA, Sareen D
2017PMID 28193854
Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy
Woo CJ, Maier VK, Davey R, Brennan J, Li G, Brothers J, et al.
2017PMID 28132888
Differentiation of Human Induced Pluripotent Stem Cells to Mammary-like Organoids
Qu Y, Han B, Gao B, Bose S, Gong Y, Wawrowsky K, et al.
2016PMID 27536002
Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease
Vazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, et al.
Nucleic acids research · 44(22):10960-10973
2016PMID 27400789
Human Induced Pluripotent Stem Cells Differentiate Into Functional Mesenchymal Stem Cells and Repair Bone Defects
Sheyn D, Ben-David S, Shapiro G, De Mel S, Bez M, Ornelas L, et al.
2016PMID 27428653
ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks
Ho R, Sances S, Gowing G, Amoroso MW, O'Rourke JG, Sahabian A, et al.
2016PMID 27550649
Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs
Qu Y, Zhou B, Yang W, Han B, Yu-Rice Y, Gao B, et al.
2016PMID 27146274
Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells
Milani P, Escalante-Chong R, Shelley BC, Patel-Murray NL, Xin X, Adam M, et al.
2016PMID 27021939
Modeling ALS with motor neurons derived from human induced pluripotent stem cells
Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, et al.
2016PMID 26793058
Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development
Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus AS, Botting CH, et al.
2015PMID 26185257
Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells
Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, et al.
2015PMID 25869002
Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model
Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, et al.
2015PMID 25740845
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, et al.
2014PMID 25298370
Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines
Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, et al.
2014PMID 25069777
Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium
Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, et al.
2014PMID 24963047
miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer
Josson S, Gururajan M, Hu P, Shao C, Chu GY, Zhau HE, et al.
2014PMID 24610630
Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord
Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, et al.
2014PMID 24559391
Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1
Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, et al.
2014PMID 24440640
Neonatal immune-tolerance in mice does not prevent xenograft rejection
Mattis VB, Wakeman DR, Tom C, Dodiya HB, Yeung SY, Tran AH, et al.
2013PMID 24236148
A simple alkaline method for decellularizing human amniotic membrane for cell culture
Saghizadeh M, Winkler MA, Kramerov AA, Hemmati DM, Ghiam CA, Dimitrijevich SD, et al.
2013PMID 24154603
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, et al.
2013PMID 23474892
EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs
Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, et al.
2012PMID 22723941
Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy
Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN
2010PMID 21030678
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics
Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, et al.
2009PMID 19898616
Chromosome 7 and 19 trisomy in cultured human neural progenitor cells
Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, et al.
2008PMID 18385041
Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction
van Ginkel PR, Darjatmoko SR, Sareen D, Subramanian L, Bhattacharya S, Lindstrom MJ, et al.
2007PMID 17848600
Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer
Sareen D, Darjatmoko SR, Albert DM, Polans AS
Molecular pharmacology · 72(6):1466-75
2007PMID 17785572
Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria
van Ginkel PR, Sareen D, Subramanian L, Walker Q, Darjatmoko SR, Lindstrom MJ, et al.
Clinical cancer research : an official journal of the American Association for Cancer Research · 13(17):5162-9
2006PMID 16936077
Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells
Sareen D, van Ginkel PR, Takach JC, Mohiuddin A, Darjatmoko SR, Albert DM, et al.
Investigative ophthalmology & visual science · 47(9):3708-16