Platform 03 · Building complexity from the ground up.
Bioengineered Tissues & Organoids
We build multi-cellular tissue architectures that recapitulate native organ physiology — from vascularized cardiac constructs to bioengineered pancreas systems and organ-on-chip platforms.
Overview
Our bioengineering programs integrate iPSC-derived cell types with engineered biomaterial scaffolds and microfluidic systems to create physiologically relevant tissue models. These platforms serve dual purposes: disease modeling for drug discovery and next-generation alternatives to animal models (NAMs) for regulatory studies.
Key programs include vascularized cardiac tissue constructs for heart failure modeling, prevascularized organoids for transplantation research, a bioengineered pancreas platform for T1D, and NMJ-on-chip and spinal cord chip systems for neuromuscular disease.
Platforms
Vascularized Cardiac Tissue
3D cardiac constructs with integrated vasculature for contractility and perfusion studies.
Bioengineered Pancreas
iPSC-derived islet organoids co-cultured with vascular and stromal cell types in biomaterial scaffolds.
NMJ-on-Chip
Microfluidic systems modeling neuromuscular junction disease including ALS and SMA.
Vascular Organoids
Self-assembling vascular organoid systems for angiogenesis research and disease modeling.
Intestinal Systems
Patient iPSC-derived intestinal organoids for cystic fibrosis and GI disease modeling.
Placental Organoids
Models of placental development and preeclampsia for maternal-fetal medicine research.