Team
Sareen Lab
Led by Dr. Dhruv Sareen at the Cedars-Sinai Biomanufacturing Center — a 25,000 sq ft cGMP facility built for clinical-grade cell and gene therapy manufacturing.
Photo coming soon
Title
Chief Biomanufacturing Officer & Executive Director
Institution
Cedars-Sinai Medical Center
Associate Professor
Also
Director, iPSC Core
Board of Governors Regenerative Medicine Institute
Principal Investigator
Dhruv Sareen, PhD
Building next-generation cell and gene therapy platforms — accelerating clinical translation with iPSC technology at the core, at scale and at speed.
Dhruv Sareen is the founding Executive Director and Chief Biomanufacturing Officer of the Cedars-Sinai Biomanufacturing Center — a 25,000 sq ft cGMP facility with ISO-certified cleanroom suites, automated differentiation labs, and AI-integrated bioprocessing infrastructure built to support human IND-enabling clinical trials.
His lab develops iPSC-derived cell therapy platforms across vascular, metabolic, cardiac, and neurological disease, with a unified manufacturing backbone spanning allogeneic and autologous programs. He led the Answer ALS consortium's iPSC biorepository — the world's largest, with over 1,200 patient lines and more than 4,000 clonal iPSCs distributed globally. The CBC operates as a Partnership Development Manufacturing Organization (PDMO): an academic-industrial engine providing cGMP manufacturing services, incubating early-stage companies, and translating novel therapies toward IND.
Education
Postdoctoral Fellow, Stem Cells & Neuroscience
University of Wisconsin–Madison · 2007–2010
PhD, Biomolecular Chemistry
University of Wisconsin–Madison · 2002–2007
BTech, Chemical Technology
University of Mumbai Institute of Chemical Technology · 1998–2002
Affiliations
Grant Portfolio
Selected grant funding.
Active — PI / Co-PI
Breakthrough T1D
Scalable GMP manufacturing of iPSC-derived insulin-producing cells
$600K
Breakthrough T1D / UHN
Process development with clinical-grade iPSC lines for beta cell biomanufacturing facility
$871K
DoD / MTEC
Quality management processes for hiPSC-derived vascular cell therapies
$3.12M
NASA / Space Tango
Stem cell production capabilities for ISS
$500K
Active — Co-Investigator
CIRM INFR5
CGT Manufacturing Network — comprehensive biomanufacturing center
$7.96M total
NIH NIDDK
Personalized cystic fibrosis therapy — iPSC CF organ models
$1.24M/yr
NIH NHLBI
Mechanisms of sex-biased risk in aneurysm — Marfan iPSC models
$1.67M
NIH NICHD
Placental organoids to model preeclampsia
$2.09M
NIH NCI
Nanoimmunodrug for glioma — GMP translation
$2.73M
NIH NIDDK
Advanced in vitro model systems — digestive disease research core
$1.43M
Selected Past Funding
CIRM Infrastructure
Biomanufacturing center solving CGT bottlenecks
$2M
Answer ALS
ALS iPSC and motor neuron biorepository
$2.85M
NIH LINCS
NeuroLINCS multi-omics — neuron and glial signatures
$196K (CSMC)
CIRM Translational
Personalized cell therapy for diabetes
The Team
Lab members.
Full profiles coming soon. Reach out at Dhruv.Sareen@cshs.org for lab inquiries.
Staff Scientist
iPSC Core Operations
Research Associate
Cell Therapy Manufacturing
Postdoctoral Fellow
Vascular Biology
Postdoctoral Fellow
Islet Differentiation
Graduate Student
Bioengineered Tissues
Graduate Student
Neurological Disease
Bioinformatics Scientist
Multi-omics & AI
Program Manager
GMP Operations